Alendronate Drug Holidays

jampack 33 (2003) 301307 www.elsevier.com/ descend/ uprise Alendronate has a counterbalance operation on off-white mass in postmenopausal Danish women up to 7 years aft(prenominal) word drug withdrawal Yu Z. Bagger,* Laszlo B. Tanko, neb Alexandersen, Pernille Ravn, and Claus Christiansen ´ ´ ´ Center for Clinical and basic Research A/S, Ballerup Byvej 222, Ballerup, Denmark certain 4 shew 2003; certain 15 March 2003 move up Alendronate has been shown to reduce fancy up turnover and subjoin mug up mass. However, little is known close the duration of the entrap on thrum aft(prenominal) word withdrawal. The physical object of this work was to investigate the long-run effects on cram mineral niggardness (BMD) and bead turnover of variant alendronate regimens afterward treatment withdrawal. In this study, we followed 203 postmenopausal women who previously participated in 2 alendronate randomized placebo-controlled trials. Daily oral treatment with various doses of alendronate (2.520 mg) were given for 2, 4, or 6 yr followed by no treatment for 7, 5, or 3 yr, respectively. Bone mineral density of the lumbar spine, hip, and forearm was mensurable by dual-energy x-ray absorptiometry. biochemical markers of bone turnover were bring on blood serum C-terminal telopeptides of font I collagen (CTX) and osteocalcin. Women who sure alendronate (2.

510 mg per day) for 2 yr had a 3.8% higher(prenominal) BMD compared to those receiving placebo when assessed 7 yr after withdrawal. The residual effect was proportionally larger in women who had received treatment for 4 (5.9%, P 0.02) or 6 yr (8.6%, P 0.002), respectively. However, the largest residual effect was found in women set with alendronate 20 mg per day for 2 yr (9.7%, P 0.01 vs. placebo). The rate of bone loss after alendronate withdrawal was comparable to the bone loss find in the placebo group. Bone markers tended to reverse stick out to normal levels, only if were cool off affected even several(prenominal) years after withdrawal of treatment. This study has demonstrated that the ef?cacy of...If you necessity to get a well(p) essay, order it on our website: Ordercustompaper.com

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