Genetic Abnormality in HIV

More than half of the work force had higher viral concentrations in their semen than in their blood. hands who had taken reverse transcriptase inhibitors had drug- large-minded strains in their semen. octonary of ten men who had genetically analyzed HIV-1 had new resistant strains in the blood, semen or both. This paper clearly documents that knowledgeable fluids or genital secretions do contain resistant virus, so spread of resistance is logical on scientific evidence.

The finding of ever increasing numbers of genetically different strains of virus, plane within one person makes word more problematical and spread more likely. Strains change by genetic mutation, and whitethorn become resistant to current drug therapy.

The common or so effective treatment for AIDS appears to be a crew of protease inhibitors (DeNoon, 1999, p. NA1). Suggested drugs are saquinavir, indinavid (Crixivan), ritonavir (Norvir), and nelfinavir (Viracept). Saquinavir has been engraft to increase the serum concentration of other protease inhibitors given over concurrently. The U. S. National Institutes of Health also recommend using any(prenominal) new experimental drugs, including the nucleoside-based reverse transcriptase inhibitors adefovir (Preveon, Gilead), and abacacir, and the non-nucleoside reverse transcriptase inhibitor efavirenz (Sustiva). Ped

Deas-Nesmith, D., Brady, K. T., White, R., & Campbell, S. (1999). HIV-Risk behaviors in adolescent nitty-gritty abusers. Journal of Substance Abuse & Treatment, 16, pp. 169-172.

In many industrialized countries, infection with HIV is one of the leading causes of mortality in adults below age 45 (Gebhardt, Neuenschwander and Zwahlen, 1998, p. 595). In the United States in 1996, 11 share of the 68,473 reported AIDS cases occurred in people 50 years of age or former(a) (AIDS Among Persons aged(a) 50, 1998, p. 575). The incidence of AIDS-related opportunistic infections in this age group increase 22 percent between 1991 and 1995, compared to a 9 percent increase in younger age groups.

Many of the older AIDS patients died within one month of the diagnosis, indicating that their diagnosis had been significantly delayed.

Nicasstri, F., Ercoli, L., Sarmati, L., Ventura, L., Guiseppe, P. S., Ciapetti, C., Montano, M., & Andreoni, M. (1998). Five human immunodeficiency virus type 1 phenotypic variants with different MT-2 cell tropisms correlate with prognostic markers of disease. Journal of gay Virology, 2, pp. 90-95.

Robbins, K. E., Kostrikis, L. G., Brown, T. M., Anzala, O., Shin, S., Plummer, F. A., & Kalish, M. L. (1999). Genetic abridgment of human immunodeficiency virus type 1 strains in Kenya: a comparison using phylogenetic analysis and a combinatorial melting assay. AIDS Research & piece Retroviruses, 15, pp. 329-325.

The immunologic and virologic activity of nevirapine in combination with 2 nucleosides (zidovudine and didanosine) was evaluated in antiretroviral-naive patients. The study showed that a triple combination of zidovudine plus didanosine and nevirapine used as a first off line regimen induced sustained virologic and immunologic repartee in AIDS patients. A study combined treatment with zidovudine and recombinant interferon-alpha2b compared to zidovudine alone. Subjects receiving combination therapy showed significantly greater we
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